Indaziflam is a cellulose biosynthesis-inhibiting herbicide for preemergence control of annual broadleaf and grass weed species in warm-season turf systems.  Bayer Crop Science recently registered this alkylazine chemical family member under the trade name Esplanade 200 SC^® for use sites including, but not limited to non-irrigation ditch banks, rights-of-way, and roadsides. Field trials were conducted along North Carolina guardrails in 2009 and 2012 to evaluate weed control with indaziflam.  Regimens included indaziflam (20 or 40 g ha^-1) and prodiamine (1.7 kg ha^-1) + simazine (2.2 kg ha^-1) in 2009, while indaziflam (51 or 73 g ha^-1) coupled with combinations of aminocyclopyrachlor (208 g ha^-1), aminopyralid (123 g ha^-1), metsulfuron (42 or 67 g ha^-1), sulfometuron (158 g ha^-1), or topramazone (92 g ha^-1) were compared to current roadside vegetation management regimens in 2012.  Trials in 2012 were initiated early May or June.  All regimens included glyphosate applied at 3.2 or 2.2 kg ha^-1 in 2009 and 2012, respectively.  In 2009, indaziflam (40 g ha^-1) + glyphosate provided > 90% cudweed (Gnaphalium spp.), dogfennel (Eupatorium capillifolium), large crabgrass (Digitaria sanguinalis), and spiny sowthistle (Sonchus asper) control through 138 days after treatment.  In 2012, regimens including indaziflam (73 g ha^-1) did not improve broomsedge (Andropogon virginicus) control compared to glyphosate applied alone; however, its addition increased large crabgrass control > 32 and 20 % following May and June application timings, respectively.  In general, regimens initiated in early June provided greater control than early May.  Finally, all regimens including indaziflam at 73 g ha^-1 provided comparable or greater control to currently utilized regimens; however, the addition of all evaluated herbicide combinations did not improve efficacy compared to indaziflam + glyphosate.  These data indicate indaziflam offers an effective herbicide option for select species and compliments existing treatment regimes along warm-season roadsides.